ࡱ> q`bjbjqPqP 1N::,t(RRRRRRRf8l2fiNfBB(jjjEEE4M6M6M6M6M6M6M$Oh7RZMREEEEEZMRRjj#NOOOERjRj4MOE4MOO(hRR(j6 `L $h(-9N0iNx(|RBR (RR(EEOEEEEEZMZMXEEEiNEEEEfffd ffffffRRRRRR  !" !"   " & &"*       " !"  !$/  !"    /", !   /    *  % $" !!B@0=00;0@85= A57>= /<5A5F8/ 07?@>AB@0=5=85 =0 <0;0@8OB0 8 @8A: >B 70@07O20=584 =0 ?@8G8=8B5;O 578AB5=-B=>AB :J<:5:0@AB25= ?@>4C:B 70 E8<8>?@>D8;0:B8:01234567 $  1. ;68@ 10/11-4/5 0;:8 ;>:0;=8 >3=8I0 =0 P.vivax A0 @538AB@8@0=8 2 6 N3>87B>G=8 @09>=0 (4@0@, ; C54, E0@409O, ;878, C0@30, "0<0=@0A5B). 7>;8@0=> <5AB=> @07?>AB@0=5=85 =0 P.falciparum 5 18;> @538AB@8@0=> 2 420 >B =09-N6=8B5 @09>=8. 0B> FO;> @8A:JB 2 ;68@ 5 =57=0G8B5;5=. P.vivax P. falciparum - - @5?>@JG20 A5 87?>;7C20=5B> =0 @5?5;5=B8 8 ?@54?07=8 <@568 A@5IC :><0@8B5. (I)2.=3>;01-12>2A5<5AB=>.P.falciparumCHL, SPMEF, MAL (IV)3.5=8=1-12>2A5<5AB=>.P.falciparumCHL, SPMEF, MAL (IV)4.>BA20=011-5/6!525@=0 G0AB: @09>= >B5B8, '>15, 30<8;5=4, :020=3>, "CBC<5.P.falciparumCHLMEF, MAL (IV)  @8A:>28B5 @09>=8.5.C@:8=0 $0A>1-12>2A5<5AB=>.P.falciparumCHL, SPMEF, MAL (IV)6.C@C=481-12>2A5<5AB=>.P.falciparumCHL, SPMEF, MAL (IV)701>=1-12>2A5<5AB=>.P.falciparumCHL, SPMEF, MAL (IV)8.0<18O1-12>2A5<5AB=>.P.falciparumCHL, SPMEF, MAL (IV)9.0=01-12>2A5<5AB=>.P.falciparumCHL, SPMEF, MAL (IV)10.28=5O1-12>2A5<5AB=>.P.falciparumCHLMEF, MAL (IV)11.28=5O 8A0C1-12>2A5<5AB=>.P.falciparumCHL, SPMEF, MAL (IV)12.681CB81-12>2A5<5AB=>.P.falciparumCHL, SPMEF, MAL (IV)13.  >=3> /08@/ 1-12>2A5<5AB=>.P.falciparumCHL, SPMEF, MAL (IV)14. 38?5B6-10=>3> <0;J: @8A: >B 70@07O20=5 2 >1;0ABB0 ; $09N<. OB 19983. =O<0 >1O25=8 A;CG08 =0 <0;0@8O.P.falciparum P.vivax-15.:20B>@80;=0 28=5O1-12 >2A5<5AB=>. P.falciparum CHL, SPMEF, MAL (IV)16. B8>?8O 1-12 >2A5<5AB=> ?>4 2000< =04<>@A:0 28A>G8=0. O<0 @8A: 2 48A 1510. P.falciparum 60% P.vivax 40% CHL, SP MEF, MAL (IV) 17. @8B@5O 1-12 >2A5<5AB=> ?>4 2200< =04<>@A:0 28A>G8=0. O<0 @8A: 2 A<0@0.P.falciparum CHL, SP MEF, MAL (IV) 18.0<18O1-12>2A5<5AB=>, 2:;NG8B5;=> 8 CA0:0.P.falciparum CHL, SPMEF, MAL (IV)19.8<1012511-6 >2A5<5AB=> ?>4 1200<. 04<>@A:0 28A>G8=0. 07?@>AB@0=5=85B> 5 F5;>3>48H=> 2 4>;8=0B0 0<1578.  %0@0@5 8 C;0C09> @8A:JB 5 <8=8<0;5=.P.falciparum CHL, SPMEF, MAL (IV)20.0<5@C=1-12>2A5<5AB=>.P.falciparumCHL, SPMEF, MAL (IV)21.0?5 5@459-113@0=8G5= @8A: =0 >AB@>2 !0> "803>, :J45B> 5 8<0;> 16 A;CG0O =0 <5AB=0 <0;0@8O ?@57 2008 3.P.falciparum 5?5;5=B8 8 ?@54?07=8 <@568 A@5IC :><0@8B5. (I)22.5=8O 1-12>2A5<5AB=> 8 F5;>3>48H=> @07?@>AB@0=5=85, :0B> 5 A@02=8B5;=> ?>-<0;J: @8A:0 2 09@>18 (8 =04 2500<.) 8 AJI> 2 F5=B@0;=8B5, 87B>G=8B5 8 70?04=8B5 ?@>28=F88, :0:B> 8 2 8DB 0;8 8 80=70. P.falciparum CHL, SPMEF, MAL (IV)23.>=3>1-12>2A5<5AB=>. P.falciparumCHL, SPMEF, MAL (IV)24.><>@A:8 >AB@>281-12>2A5<5AB=>.P.falciparumCHL, SPMEF, MAL (IV)25.>B  2>0@1-12>2A5<5AB=>.P.falciparumCHL, SPMEF, MAL (IV)26.815@8O1-12>2A5<5AB=>.P.falciparumCHL, SPMEF, MAL (IV)27. 02@8B0=8O1-12 7-10 8A: 8<0 2 FO;0B0 AB@0=0 A 87:;NG5=85 =0 A525@=8B5 @09>=8: 0:E;5B->C04E81>C 8 "8@8A-5<>C@. 8A: >B <0;0@8O AJI5AB2C20 ?@57 4J64>2=8O ?5@8>4 2 4@0@ 8 =G8@8. P.falciparum CHL MEF, MAL (IV)28.AB@>2 04030A:0@1-12>2A5<5AB=>. ! =09-28A>: @8A: A0 :@091@56=8B5 @09>=8.P.falciparumCHL MEF, MAL (IV) 29.09>B51-12<0 @8A: 3;02=> 70 B@>?8G5A:0 <0;0@8O.P.falciparumCHL, SPMEF, MAL (IV)30.0;0281-12>2A5<5AB=>.P.falciparumCHL, SPMEF, MAL (IV)31.0;81-12>2A5<5AB=>.P.falciparumCHL, SPMEF, MAL (IV)32. 0@>:>5-10!J2A5< >3@0=8G5= @8A: 2 =O:>8 A5;A:8 @09>=0 2 ?@>28=F8O '5DG0>C5=. O<0 @538AB@8@0=8 <5AB=8 A;CG08 >B 20053. P.vivax - -33.>70<18:1-12>2A5<5AB=>.P.falciparumCHL, SPMEF, MAL (IV)34.0<818O11-60;8F5 5 @8A: 2 @09>=8B5 H0=0, H8:>B>, <CA0B8,<0E5:5, E0=325=0 8 B6>7>=46C?0. > ?@>B565=85 =0 @5:8B5 020=3>, C=5=5 8 @09>= 0?@828 @07?@>AB@0=5=85B> 5 F5;>3>48H=>.P.falciparumCHL, SPMEF, MAL (IV) (A0<> 2 @8A:>28B5 @09>=8).35.835@1-12>2A5<5AB=>.P.falciparumCHLMEF, MAL (IV)36.835@8O1-12>2A5<5AB=>.P.falciparumCHL, SPMEF, MAL (IV)37. C0=401-12>2A5<5AB=>.P.falciparumCHL, SPMEF, MAL (IV)38.!0> "><5 8 @8=A8?81-12>2A5<5AB=>.P.falciparumCHLMEF, MAL (IV) 39.!2078;5=41-12J2 2A8G:8 =8A:8 @02=8==8 @09>=8 (?@548<=> 83 5=4, E;C<5, !8<C=85 8 "H0=5=8).P.falciparumCHLMEF, MAL (IV)40.!5=530;1-12>2A5<5AB=>. >-<0;J: @8A: 8<0 >B O=C0@8 4> N=8 2 F5=B@0;=8B5 70?04=8 @09>=8.P.falciparumCHL, SPMEF, MAL (IV)41.!><0;8O1-12>2A5<5AB=>, :0B> @8A:JB 5 >B=>A8B5;=> ?>-=8AJ: 8 A57>=5= 2 A525@=0B0 G0AB =0 AB@0=0B0 8 AJ>B25B=> 7=0G8B5;=> ?>-28A>: 2 F5=B@0;=0B0 8 N6=8B5 G0AB8.P.falciparumCHL, SPMEF, MAL (IV)42.!C40=1-12>2A5<5AB=>. 8A:JB 5 =8AJ: 2 A525@=0B0 G0AB =0 AB@0=0B0 (A57>=5=). 8A>: @8A: 8<0 2 F5=B@0;=0B0 8 N6=0 G0AB =0 AB@0=0B0. 8A:JB >B <0;0@8O 5 <=>3> >3@0=8G5= ?> :@091@5685B> =0 '5@25=> <>@5.P.falciparum CHL, SPMEF, MAL (IV)43.!85@0 5>=51-12>2A5<5AB=>.P.falciparumCHL, SPMEF, MAL (IV)44."0=70=8O1-12>2A5<5AB=>, ?>4 1800<.P.falciparumCHL, SPMEF, MAL (IV)45.">3>1-12>2A5<5AB=>.P.falciparumCHLMEF, MAL (IV)46. #30=40 1-12 >2A5<5AB=>, 2:;NG8B5;=> 8 2 3;02=8B5 3@04>25: $>@B >@B0;, 68=460, 0<?0;0, 10;5 8 83578.P.falciparum CHL, SP MEF, MAL (IV) 47.&5=B@0;=0 D@8:0=A:0 5?C1;8:01-12>2A5<5AB=>.P.falciparumCHL, SPMEF, MAL (IV)48.'041-12>2A5<5AB=>.P.falciparumCHL, SPMEF, MAL (IV)49..  1-12 @09>=8 A <0;:0 =04<>@A:0 28A>G8=0 2 A525@=0B0 G0AB, ?@>28=F8O ?C<0;0=30 (2:;. 0F. 0@:  @N35@ ) 8 A525@>87B>G5= 20 C;C-0B0; =0 N3 4> @5:0 "C35;0. 8A:JB 5 F5;>3>48H5=, => 5 =09-28A>: >B >:B><2@8 4> <09.P.falciparumCHL, SPMEF, MAL 2 @8A:>28B5 @09>=8. (IV)  1234567 /  / 1.@<5=8O6-10 =O:>8 A5;0 2 4>;8=0B0 @0@0B, 3;02=> 2 >1;0AB 0A8A. O<0 @8A: 2 BC@8AB8G5A:8B5 @09>=8. O<0 @538AB@8@0=8 <5AB=8 A;CG08 >B 20063.P.vivax - 5?5;5=B8 8 70I8B=8 <@568 A@5IC :><0@8. (I)2.75@109460=6-10!JI5AB2C20 >3@0=8G5= @8A: >B <0;0@8O 2 =878=8B5, 3;02=> 2 @09>=8B5 <564C @5:8B5 C@0 8 @0:A. P.vivax -CHL (II)3.D30=8AB0=5-11>4 2000< =04<>@A:0 28A>G8=0.P.vivax P.falciparumCHL, SPMEF, MAL (IV)4. 0=3;045H1-12>2A5<5AB=> A 87:;NG5=85 =0 3@.0:0. 09-28A>: @8A: AJI5AB2C20 2 '8B03>=3, :0:B> 8 2 @09>=8B5 =0 8<5=78=E, 5B@0:>=0, (5@?C@ 8 C@83@0<. P.falciparum CHL,SPMEF, MAL (IV)5. CB0= 1-12  N6=0B0 G0AB =0 5 >1;0AB8: 'EC:E0, !0<G8, !0<4@C?-6>=:E0@, 59;53-DC3 8 (5<30=3.P.falciparum CHL, SP MEF, MAL (IV) 2 @8A:>28B5 @09>=8.6.0=C0BC1-12>2A5<5AB=> ->B =8AJ: 4> C<5@5= @8A: >B 70@07O20=5.P.falciparum P.vivaxCHL, SP CHLCHL +  (III)7.@C78O7-10!JI5AB2C20 @8A: >B <0;0@8O B5@F80=0 ?@57 ;5B=8B5 <5A5F8 /N;8->:B><2@8/ 2 N3>87B>G=0B0 G0AB =0 AB@0=0B0.P.vivax  5?5;5=B8 8 70I8B=8 <@568 A@5IC :><0@8. (I)8.5<5=1-12>2A5<5AB=> ?>4 2000<. >-28A>: @8A: >B 70@07O20=5 8<0 2 ?5@8>40 A5?B5<2@8-D52@C0@8. O<0 @8A: 2 AB>;8F0B0 !0=0`0. 8A:JB =0 >AB@>2 !>:>B@0 5 >3@0=8G5=.P.falciparumCHL, SP @8A:>28B5 @09>=8: MEF, MAL. (IV) 5?5;5=B8 8 ?@54?07=8 <@568 A@5IC :><0@8 =0 >AB@>2 !>:>B@0. (I) 9.=48O1-12>2A5<5AB=> ?>4 2000 < A 87:;NG5=85 =0 I0B8B5 %8<0G0; @045H, 60<C, 0H<8@ 8 !8:8<. 8A:0 >B @578AB5=B5= P.falciparum 5 ?>-28A>: 2 A525@>87B>G=8B5 I0B8 =40<0=, >AB@>28B5 8:>10@, E0B8A30@E, >0, C60@0B, 60@:E0=4, 0@=0B0:0 (A 87:;NG5=85 =0 3@04 0=30;>@5), 04E8O @045H, 0E0@0HB@0 (A 87:;NG5=85 =0 3@04>25B5 C<109, 03?C@, 0A8: 8 C=8), @8A0 8 0?045= 5=30; (A 87:;NG5=85 =0 3@04 0;:CB0 ).P.falciparum (40-50%) P.vivax (50-60%)CHL, SP MEF, MAL (IV)  2 871@>5=8B5 @8A:>28 @09>=8. CHL+  (III)  2 ?>25G5B> G0AB8 =0 AB@0=0B0. 10.=4>=578O1-1209-28A>: @8A: >B <0;0@8O 8<0 2 ?5B 87B>G=8 ?@>28=F88: 8AB CA0 "5=30@0, 0;C:C, >@B 0;C:C, 0?C0 8 #5AB 0?C0.  >AB0=0;8B5 G0AB8 =0 AB@0=0B0 @8A:0 5 >3@0=8G5= 8 A2545= >B =8AJ: 4> =5AJI5AB2C20I 2 60:0@B0, 3>;5<8B5 3@04>25 8 ?>25G5B> 3>;5<8 BC@8AB8G5A:8 >15:B8. 538AB@8@0= 5 A;CG09 =0 8=D5:F8O A P.knowlesi 2 ?@>28=F8O 0;8<0=B0=. P.falciparum P.vivaxCHL, SP CHLMEF, MAL (IV)  2 @8A:>28B5 @09>=8.11.@0=3-11 8A: >B <0;0@8O B5@F80=0 (P.vivax) 8 >B <0;0@8O B@>?8:0 (P.falciparum) 8<0 2 A5;A:8B5 @538>=8 =0 ?@>28=F88B5 %>@<>730=, 5@<0= (B@>?8G5A:0B0 G0AB) 8 N6=0B0 G0AB =0 !8AB0=-0;CG5AB0=. P.falciparum P.vivaxCHL, SP MEF, MAL (IV) 12.@0:5-11 A525@=8B5 @09>=8 ?>4 1500< (CE>:, @18; 8 !C;09<0=8O). P.vivax-CHL (II)13. 0<1>4601-12>2A5<5AB=> A 87:;NG5=85 =0 =>< 5= 8 >:>;> ">=;5 !0;. 0;0@8O <>65 40 A5 >B:@85 8 2 BC@8AB8G5A:8B5 @09>=8 =0 =3:>@ 0B. 538AB@8@0=8 A0 A;CG08 =0 8=D5:F8O A I0<>25 =0 P.falciparum, @578AB5=B=8 =0 <5D;>:8= 8 5 CAB0=>25= B>;5@0=A :J< 0@B5AC=0B 2 N3>-70?04=8B5 ?@>28=F88. P.falciparumCHL, SP MEF  2 N3>-70?04=8B5 ?@>28=F88. MEF, MAL (IV) (2:;. 8 2 =3:>@ 0B). MAL, D% (IV)- 2 N3>-70?04=8B5 ?@>28=F88.14. 8B09 7-11  ?@>28=F88 %09=0= 8 .==0= 5 @07?@>AB@0=5=0 <0;0@8O B@>?8:0. !J>1I020 A5 70 P.falciparum A <=>65AB25=0 ;5:0@AB25=0 @578AB5=B=>AB. 3@0=8G5= @8A: >B <0;0@8O B5@F80=0 AJI5AB2C20 2 =O:>8 N6=8 8 F5=B@0;=8 ?@>28=F88 :0B> =EC8, N87EC, %N159, %N=0=, /=3AC. 5 AJI5AB2C20 @8A: 2 C@10=878@0=8B5 @09>=8.P.falciparum P.vivax CHL, SP MEF, MAL (IV)  2 %09=0= 8 .==0=. CHL (II)  2 @8A:>28B5 @09>=8.15.8@387AB0=6  10 8A: >B 70@07O20=5, >A=>2=> A P.vivax >B N=8 4> >:B><2@8 2 =O:>8 N6=8 8 70?04=8 G0AB8 =0 AB@0=0B0, 3;02=> 2 0B:5=, H 8 >1;0AB 60;0;0104A:0, 2 @09>=8, 3@0=8G=8 =0 "0468:8AB0= 8 #715:8AB0= 8 2 ?@543@048OB0 =0 8H:5:.P.vivax- 5?5;5=B8 8 70I8B=8 <@568 A@5IC :><0@8. (I)16.>@59A:0 5<>:@0B8G=0 0@>4=0 5?C1;8:03@0=8G5= @8A: >B 70@07O20=5 2 =O:>8 N6=8 @09>=8.P.vivax- 5?5;5=B8 8 70I8B=8 <@568 A@5IC :><0@8. (I)17. 5?C1;8:0 >@5O3@0=8G5= @8A: >B 70@07O20=5 8<0 3;02=> 2 A525@=8B5 @09>=8 =0 ?@>28=F88B5 N=468 > 8 0=3C>=E >.P.vivax- 5?5;5=B8 8 70I8B=8 <@568 A@5IC :><0@8. (I)18. CA:0 $545@0F8O!J2A5< >3@0=8G5= @8A: AJI5AB2C20 2 @09>=8, :J45B> 8<0 70A8;5=0 <83@0F8O >B N6=8 AJA54=8 AB@0=8.P.vivax--19.0>A1-12>2A5<5AB=>, >A25= 2J2 85=B80=. P.falciparumCHL, SPMEF, MAL (IV)20.0;0978O1-12 8A: A0<> 2 >3@0=8G5=8 @09>=8 2J2 2JB@5H=>ABB0 =0 AB@0=0B0.  C@10=878@0=8B5 8 :@091@56=8 @09>=8 =O<0 <0;0@8O. 538AB@8@0=8 A0 A;CG08 =0 8=D5:F8O A G>25H:8 P. knowlesi.P.falciparumCHL, SPMEF, MAL (IV)  2 @8A:>28B5 @09>=8. 21.80=<0@ /8@<0/1-12 &5;>3>48H=> ?>4 1000< =04<>@A:0 28A>G8=0, A 87:;NG5=85 =0 3@04A:8B5 7>=8 =0 /=3>= 8 0=40;09. 8A:JB 5 <=>3> 28A>: 2 >B40;5G5=8B5 A5;A:8 @09>=8. 5D;>:8= @578AB5=B=8 I0<>25 =0 P.falciparum A0 CAB0=>25=8 2 I0B8B5 09O= 8 (0=- 87B>G=0B0 G0AB. B:@8B8 A0 I0<>25 =0 P.vivax A =0<0;5=0 GC2AB28B5;=>AB :J< E;>@>:8=. 538AB@8@0=8 A0 8 A;CG08 =0 8=D5:F8O A P.knowlesi.P.falciparum P.vivaxCHL, SP, MEF CHLMAL, DOX (IV) 2 >1;0AB 09O= 8 87B>G=8B5 G0AB8 =0 >:@J3 (0=. MEF, MAL (IV)22.5?0;1-12 A5;A:8B5 @09>=8 =0 >1;0ABB0 "5@08 (2:;. 3>@8B5 8 3>@A:8B5 A5;8I0) 8 >A>15=> ?>3@0=8G=8B5 7>=8 A =48O. ?0A=>ABB0 >B 70@070 A P.falciparum 5 =09-3>;O<0 ?@57 <5A5F8B5 >B N;8 4> >:B><2@8. P.vivax P.falciparum CHL, SPCHL+  (III)23.<0=1-12!?>@048G=8 A;CG08 =0 B@0=A<8A88 =0 P.falciparum 8 =0 P.vivax A0 4>:;0420=8 4> 20033., ?@57 20073. - 4 A;CG0O =0 P.vivax 8 ?@57 20083. 8<0 >B=>2> 8 A;CG0O =0 P.vivax. P.falciparum P.vivax--24. 0:8AB0=1-12>2A5<5AB=> ?>4 2000<. P.falciparum P.vivax CHL, SP -MEF, MAL (IV) -25.0?C0 >20 28=5O1-12 >2A5<5AB=> ?>4 1800<. P.falciparum P.vivaxCHL, SP CHLMEF, MAL (IV)26.!0C48BA:0 @018O1-12!JI5AB2C20 @8A: ?@57 FO;0B0 3>48=0 2 ?>-3>;O<0B0 G0AB >B .3>70?04=8O @538>= /A 87:;NG5=85 =0 28A>:>?;0=8=A:8B5 @09>=8 =0 ?@>28=F8O A8@/. 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 2 @8A:>28B5 @09>=8. (III)1234567 "!   1.@65=B8=0 8A:JB 5 <0;J: 8 5 2 A5;A:8B5 @09>=8 ?> 3@0=8F0B0 A >;828O  (=878=8B5 =0 ?@>28=F8O !0;B0) 8 ?> 3@0=8F0B0 A 0@03209 (?@>28=F88 '0:> 8 8A8>=5A). .vivax CHL (II)  2 @8A:>28B5 @09>=8.2.0E0<8!?>@048G=8 ;>:0;=8 A;CG08 =0 B@0=A<8A8O =0 P.falciparum A0 CAB0=>25=8 ?@57 20083. A0<> =0 >AB@>2 @59B :AC<0. O<0 @8A: >B <0;0@8O =0 >AB0=0;8B5 >AB@>28.P.falciparum @5?>@JG20 A5 87?>;7C20=5B> =0 @5?5;5=B8 8 ?@54?07=8 <@568 A@5IC :><0@8B5. (I) 3.5;871-12>2A5<5AB=> A @07;8G5= 5:AB5=78B5B 2 >B45;=8B5 @09>=8. 09-@8A:>28 A0 @09>=8B5 ">;54> 8 !B0= @55:. 8A:JB 5 ?>-<0;J: 2 >@>70; 8 09>. 8A:JB 5 =8AJ: 2 @09>=8B5 5;875 8 @8=46 #o;:. 5 A0 CAB0=>2O20=8 @578AB5=B=8 I0<>25 =0 P. falciparum. P.vivax P.falciparum -CHL (II)4.>;828O1-120;0@8O B5@F80=0 (P.vivax) ?>4 2500< 2 FO;0B0 AB@0=0. P. falciparum, A5 >B:@820 2 !0=B0 @C7 8 A525@=8B5 @09>=8 5=8 8 0=4>. A>15=> 70A53=0B8 A0 AC1-@09>=8B5 C0C0@0<5@8=, >18460 8 815@0;B0. P.vivax - 91% P.falciparum-9% - CHL, SP CHL (II) MEF, MAL (IV) - 2 !0=B0 @C7, 5=8 8 0=4>.5.@078;8O1-1209-H8@>:> @07?@>AB@0=5=85 8<0 2 3>@8AB8B5 @09>=8 ?>4 900< =04<>@A:0 28A>G8=0 2 4525B I0B0 >B @538>=0  530; <07>=8O : :@5, <0?0, <07>=0A, 0@0=E0> (70?04=0 G0AB), 0B> @>AA> (A525@=0 G0AB), 0@0 (A 87:;NG5=85 =0 3@04 5;5<), >=4>=80, >@08<0 8 ">:0=B8A (70?04=0 G0AB). "@0=A<8A8OB0 5 <=>3> 8=B5=782=0 2 @09>=0 =0 46C=3;0B0, <8=L>@A:8, 4J@2>4>182=8 8 A5;A:>AB>?0=A:8 A5;8I0, :>8B> AJI5AB2C20B >B A:>@> (?>-<0;:> >B 5 3>48=8), :0:B> 8 2 ?5@8D5@8OB0 =0 3@04>25B5 @C759@> 4> !C;, >@B> 5;E>, 8 0=0CA. "@0=A<8A8O =0 <0;0@8O 5 CAB0=>25=0 8 2 ?>:@09=8=8B5 =0 3>;5<8B5 3@04>25 :0B> >0 8AB0, 0:0?0, 0@010, 8> @0=:> 8 !0=B0@5< 5 3;02=> 2 ?5@8D5@8OB0 =0 B578 3@04>25.  I0B8B5 872J=  530; <07>=8O @8A:JB >B 70@07O20=5 5 >B <8=8<0;5= 4> =5AJI5AB2C20I. P.vivax 84% P.falciparum 15% !<5A5=0 <0;0@8O 1% CHL I0<>25 =0 P.falciparum A <=>65AB25=0 ;5:0@AB25=0 @578AB5=B=>AB MAL, DOX (IV) 2 @8A:>28B5 @09>=8. 6.5=5FC5;01-120;0@8O B5@F80=0 (P.vivax) 8 B@>?8:0 (P.falciparum) A0 @07?@>AB@0=5=8 2 =O:>8 A5;A:8 @09>=8 =0 I0B8B5 <07>=0A, =7>0B53C8, >;820@ 8 5;B0 <0:C@>. >-=8AJ: @8A: A5 >BG8B0 2 ?C@5, >=030A, !C:@5 8 C;80. ?0A=>ABB0 >B <0;0@8O B@>?8:0 5 ?>-3>;O<0 2 46C=3;0B0 =0 I0B8B5 <07>=0A (;B> @8=>:>, B010?>, BC@5A, CB0=0, 0=0?80@5, 8> 53@>), >;820@ (0@>=8, 545=>, ; 0;0>, %5@5A, @0= !010=0, 80@, 0C; 5>=8, >F8>, !8D>=B5A 8 !C:@5).P.vivax (83%) P.falciparum (16%)  CHL, SPCHL (II) MEF, MAL (IV) - 2 871@>5=8B5 @8A:>28 @09>=8.7.20B5<0;01-12 <5AB=>AB8 ?>4 1500<. F5;>3>48H=>. !@545= 5 @8A:0 >B 70@07O20=5 A <0;0@8O 2 45?0@B0<5=B8B5 A:C8=B;0 8 7010; 8 =8AJ: 2 ;B0 5@0?07, 090 5@0?07, 5B5=, '8:C8<C;0, C8G5 8 !CG8B5?5:C57.  P.vivax - CHL (II) - 2 @8A:>28B5 @09>=8.8.280=01-12>2A5<5AB=> 2J2 2JB@5H=>ABB0 =0 AB@0=0B0, :0B> =09-28A>: @8A: A5 =01;N4020 2 @538>=8 1, 7, 8, 9 8 10, A@545= @8A: 2 @538>=8 2 8 3 8 <=>3> =8AJ: 2 4, 5 8 6. !?>@048G=8 A;CG08 A5 =01;N4020B 2 3JAB> =0A5;5=8B5 <5AB0 >B :@091@56=8B5 @09>=8.P.falciparum 45% P.vivax 51% !<5A5=8 8=D5:F88 4%CHLMEF, MAL (IV)9.><8=8:0=A:0 5?C1;8:01-12 8A: 8<0 ?@548<=> 2 70?04=8B5 ?@>28=F88 =0 0601>=, ;80A 8=0 8 !0= %C0=.  >AB0=0;8B5 @09>=8 @8A:JB 5 <0;J: 4> =57=0G8B5;5=. O<0 40==8 70 @578AB5=B=>AB =0 P.falciparum :J< =O:>8 >B 0=B8<0;0@89=8B5 ?@5?0@0B8.P.falciparum -CHL (II) - 2 @8A:>28B5 @09>=8.10.:204>@1-12&5;>3>48H=> 8<0 @8A: 2 @09>=8B5 ?>4 1500<, :0:B> AJI5AB2C20 8 C<5@5=0 25@>OB=>AB >B B@0=A<8A8O 8 2 :@091@56=8B5 ?@>28=F88. 5 AJI5AB2C20 @8A: 2 C090:C8; 8 C8B> 8 3@04>25B5 2 @538>=0 =0 =48B5.P.falciparum 8% P.vivax 92%CHL, SPMEF, MAL (IV)  70 2A8G:8 @09>=8 157 C090:C8; 8 C8B>.11. >;C<18O1-128A>: @8A: 2 46C=3;0B0 8 2 A5;A:8 @09>=8 ?>4 1600< 2 @538>=8B5 #@010 046> 0C:0, @8=>:8O, 0F8D8:> 8 <07>=8O. =B5=78B5BJB =0 B@0=A<8A8O 20@8@0 2 @07;8G=8B5 45?0@B0<5=B8, :0B> =09-28A>: 5 2 <07>=0A, =B8>:20, @0C:0, '>:>, >@4>10, C0280@5, 5B0, 0@8=>, CBC<09>, 0;5 45; 0C:0 8 8G040. 578AB5=B=8 =0 CHL I0<>25 =0 P.falciparum A5 A@5I0B 2 #@010 046> 0C:0, 0F8D8:0 8 <07>=8O. !J>1I020 A5 70 @578AB5=B=>AB :J< SP. P.falciparum 27% P.vivax 72% CHL, SP MEF, MAL (IV) - 2 #@010 046> 0C:0, 0F8D8:0 8 <07>=8O. CHL +  (III)12.>AB0 8:01-128A>: @8A: >B 70@07O20=5 A P.vivax 8<0 2 ?@>28=F88B5 =0 8<>= >A=>2=> 2 :0=B>= 0B8=0. 5AJI5AB25= 8;8 =8:0:J2 @8A: >B 70@07O20=5 A5 =01;N4020 2 4@C38B5 :0=B>=8 =0 AB@0=0B0. P.vivax - CHL (II)13.5:A8:>1-12 =O:>8 A5;A:8 @09>=8, :>8B> @O4:> A5 ?>A5I020B >B BC@8AB8. #<5@5= @8A: >B 70@07O20=5 8<0 2 >1;0AB8B5 '80?0A 8 0:A0:0 8 <=>3> =8AJ: 2 >1;0AB8B5 '8EC0EC0, C@0=3>, 09O@8B, C0=B0=0 >> 8 !8=0;>0. P.vivax-CHL (II)  2 @8A:>28B5 @09>=8.14.8:0@03C01-12 8A: >B <0;0@8O, ?@548<=> >B P. vivax, AJI5AB2C20 F5;>3>48H=>. B C<5@5= 4> 28A>: @8A: 8<0 =09-25G5 2 >1;0AB8B5 '8=0=350, 5>=, 0=03C0, 0B030;?0,  B;0=B8:> >@B5 8  B;0=B8:> !C@. 2B>EB>==8 A;CG08 A0 4>:;0420=8 8 >B 4@C38 @09>=8 2 F5=B@0;=8B5 8 70?04=8B5 45?0@B0<5=B8, => A5 AG8B0, G5 @8A:JB 2 BOE 5 <0;J:. O<0 CAB0=>25=0 E;>@>:8=>20 @578AB5=B=>AB =0 P.falciparum.P.falciparum P.vivax 92%-CHL (II) - 2 @8A:>28B5 @09>=8.15..0=0<01-12 8A: AJI5AB2C20 F5;>3>48H=> 2 ?@>28=F88B5, =0<8@0I8 A5 ?> ?@>B565=85B> =0 0B;0=B8G5A:>B> :@091@5685 8 ?> 3@0=8F0B0 A >;C<18O 8 >AB0 8:0: >:0A 45; ">@>, '8@8EC9, >;>=, 0@85=, 3>15 C3;5, 0=0<0 8 5@0320A.  3@04JB 0=0<0 8 0=0; >=5, :0:B> 8 2 4@C38B5 ?@>28=F88, @8A:JB 5 <8=8<0;5=. %;>@>:8= @578AB5=B5= P.falciparum 5 4>:;0420= 2 ?@>28=F88B5 0@85= 8 !0= ;0A.P.falciparum 1% P.vivax - 99%CHL 2 ?@>28=F8O 0@85= 8 !0= ;0A.MEF, MAL (IV) - 2 87B>G=8B5 5=45<8G=8 @09>=8. CHL (II) - 2 @8A:>28 @09>=8. 16.0@032091-12!@545= 8=B5=78B5B =0 B@0=A<8A8O 2 >?@545;5=8 >1I8=8 =0 45?0@B0<5=B8B5 ;B> 0@0=0, 003C07C 8 0=5=409C.  >AB0=0;8B5 14 45?0@B0<5=B0 @8A:JB 5 =57=0G8B5;5= 8;8 =O<0 B0:J2. P.vivax -CHL (II) - 2 @8A:>28 @09>=8.17.5@C1-12 8A:JB 5 F5;>3>48H5= 2 A5;A:8B5 @09>=8 ?>4 2000< =04<>@A:0 28A>G8=0. 23 A0 >1;0AB8B5 A 28A>: @8A: 8 B5 A0 :>=F5=B@8@0=8 2 >:@J78B5 O:CG>, .=8=, >@5B>, 04@5 5 8>A 8 !0= 0@B8=. >@5B> 5 =09-@8A:>28OB @09>= A 98% >B A;CG8B5 =0 B@>?8G5A:0 <0;0@8O, :0:B> 8 4@C38B5 45?0@B0<5=B8, @07?>;>65=8 ?>:@09 <07>=8O /2:;. 18 ?@8AB0=8I=8 A5;8I0/.P.falciparum 15% P.vivax 85%CHL, SPMEF, MAL (IV) - 2 >:@J3 >@5B>. CHL (II) 18. !0;204>@ (El Salvador)1-12=>3> =8AJ: @8A: >B 70@07O20=5 2 ?@>28=F8O !0=B0 =0 8 2 A5;A:8B5 @09>=8, 2 :>8B> 8<0 <83@0F8O >B 20B5<0;0. !?>@048G=8 A;CG08 =0 2820:A <0;0@8O, >10G5 A0 4>:;0420=8 8 >B 4@C38 G0AB8 =0 AB@0=0B0. P.vivax- 5?5;5=B8 8 ?@54?07=8 <@568 A@5IC :><0@8. (I)19.!C@8=0<1-12 8A:JB 5 3>;O< 2J2 2JB@5H=>ABB0 =0 AB@0=0B0, 872J= :091@56=0B0 A020==0 >1;0AB, :0B> 5 =09-3>;O< ?> ?@>B565=85 =0 87B>G=0B0 3@0=8F0 8 2 @09>=8B5 AJA 7;0B=8 <8=8.  3@04 0@0<0@81> 8 >AB0=0;8B5 A545< :@091@56=8 @09>=0, @8A:JB 5 <0;J: 4> =57=0G8B5;5=. P.falciparum 55% P.vivax 43% !<5A5=0 8=D. 2%CHL, SP, MEF, =0<0;5=0 GC2AB28B5;=>AB :J< E8=8=MAL, DOX (IV) - 2 @8A:>28B5 @538>=8.20.$@5=A:0 280=01-128A>: @8A: 2 4525B >1I8=8 ?> 3@0=8F0B0 A @078;8O (4>;8=0B0 =0 @5:0 9O?>:5) 8 4> 3@0=8F0B0 AJA !C@8=0< (4>;8=0B0 =0 @5:0 0@>=8).  4@C38 13 >1I8=8 @8A:JB 5 =8AJ: 4> =57=0G8B5;5=.  @09>=8B5 A <83@0F8O >B @078;8O, A5 AJ>1I020B I0<>25 P.falciparum A <=>65AB25=0 ;5:0@AB25=0 @578AB5=B=>AB.P.falciparum 45% P.vivax 55% CHL, SPMEF, MAL (IV) - 2 @8A:>28B5 @538>=8.21.%08B81-12 8A:JB >B <0;0@8O 5 F5;>3>48H5= 2 FO;0B0 AB@0=0, 2:;NG8B5;=> :@091@56=8B5 8 3@0=8G=8B5 7>=8. =>3> =8AJ: @8A: 8<0 A0<> 2 3@04A:8B5 @09>=8 =0 >@B0 @8=A5. P.falciparum-CHL (II) - 2 @8A:>28B5 @538>=8.22.%>=4C@0A1-128A>: @8A: >B <0;0@8O B5@F80=0 (P.vivax) 8<0 2 ?@>28=F88B5 @0F8OA 0 8>A 8 A@545= 2 B;0=B840, >;>=, A;0A 45 ;0 0E8O (>AB@>28 45 ;0 0E8O), ;0=G>, 0;5 8 ,>@>. 8A:JB >B . falciparum 5 =09-28A>: 2 >;>= 8 @0F8OA 0 8>A 8 C<5@5= 2 B;0=B840 8 ;0=G>.P.falciparum 7% P.vivax 93%-CHL (II)23./<09:01-12=>3> <0;J: @8A:, => 2:;NG8B5;=> 8 >B P.falciparum, 2 @09>=8B5 =0 8=3AB>= 8 %@0<0 =0 !25B8 =4@N. P.falciparum- 5?5;5=B8 8 70I8B=8 <@568 A@5IC :><0@8B5.(I)  !* )/: MEF - MEFLOQUINE CHL -CHLOROQUINE   PROGUANIL DOX  DOXYCYCLINE SP  SULFADOXINE - PYRIMETHAMINE MAL  MALARONE (A"OVAQUONE + PROGUANIL) "8?878@0=5 AB5?5=B0 =0 @8A:0 >B <0;0@8O 8A: >B <0;0@8O@5?>@JG0= B8? ?@>D8;0:B8:0"8?  I  =>3> <0;J: @8A: >B B@0=A<8A8O.@54?0720=5 >B CE0?20=8O >B :><0@8. "8?  II  8A: >B P. viv0x 8;8 =0?J;=> GCAB28B5;5= =0 chloroquine P. falciparum.@54?0720=5 >B CE0?20=8O >B :><0@8, ?;NA E8<8>?@>D8;0:B8:0 A chloroquine."8?  III  <0 @8A: >B <0;0@8O, 8<0 AJI> 8 8725AB=0 @578AB5=B=>AB :J< chloroquine C <5AB=8B5 I0<>25.@54?0720=5 >B CE0?20=8O >B :><0@8, ?;NA :><18=8@0=0 E8<8>?@>D8;0:B8:0, chloroquine+proguanil. "8?  IV  8A>: @8A: >B <0;0@8O B@>?8:0 ?;NA @578AB5=B=>AB =0 P. falciparum :J< 0=B8<0;0@89=8 A@54AB20, 8;8 C<5@5= 4> =8AJ: @8A: >B <0;0@8O B@>?8:0, => A <=>3> A8;=> 87@075=0 @578AB5=B=>AB.@54?0720=5 >B CE0?20=8O >B :><0@8, ?;NA E8<8>?@>D8;0:B8:0 c mefloquine, doxycycline, malarone (atovaquone+proguanil), :0B> A5 8718@0 A@54AB2> 70 :>5B> =5 5 4>:;0420=0 @578AB5=B=>AB 2 AJ>B25B=8O @09>=. : 8<A:8B5 F8D@8 I, II, III 8 IV A5 >B=0AOB 4> G5B8@8B5 B8?0 ?@>D8;0:B8:0 ?@5?>@JG0=8 >B ! A?>@54 :0B53>@870F8OB0 =0 ! =0 <0;0@89=8O @8A:. !%  % $"   !  !"   / @5?0@0B>78@>2:0@>4J;68B5;=>AB!?5F80;=8 3@C?8A=>2=8 :>=B@08=48:0F88><5=B0@@5<5==>ABJ@<5=55F0 Malarone (BJ@3. <0@:0) :><18=8@0=8 B01;5B:8 1) ?5480B@8G=8: -Atovaquone 62.5mg -Proguanil 25mg 2) 70 2J7@0AB=8: -Atovaquone 250mg -Proguanil 100mg 11-20:g B.<.  1 ?5480B@8G=0 B01;. 4=52=> 21-30:g B.<.  2 ?5480B@8G=8 B01;. 4=52=> 31-40:g B.<. - 3 ?5480B@8G=8 B01;. 4=52=> >40:g B.<.  1 B01;. 4=52=> 0?>G20 548= 45= ?@548 ?@8AB830=5 2 @8A:>28O @09>= 8 A5 ?@>4J;6020 7 4=8 A;54 =0?CA:0=5B> <C 8?A20B 40==8, =5 A5 ?@5?>@JG20 8?A20B 40==8, =5 A5 ?@5?>@JG20 5 A5 ?@5?>@JG20 70 45F0 ?>4 11 :3. B.<. !2@JEGCAB28B5;=>AB :J< atovaquon 8/8;8 proguanil, >AB@0 1J1@5G=0 =54>AB0BJG=>AB (:@50B8=8=>2 :;8@J=A < 30 ml/min) 538AB@8@0= 2 52@>?59A:8B5 AB@0=8 (2 J;30@8O  =5) 70 E8<8>?@>D8;0AB8:0, :0B> >3@0=8G5=85B> 70 <0:A8<0;=8O A@>: =0 C?>B@510 20@8@0 >B 5 A54<8F8 4> 1 3>48=0. ;07<5=0B0 :>=F5=B@0F8O =0 atovaquone A5 @54CF8@0 ?@8 54=>2@5<5=5= ?@85< A rifampicin, rifabutin, metoclopamide 8;8 tetracycline.Chloroquine B01;.250mg (150mg 1070)5mg 1070/kg B.<. A54<8G=> 2 54=0 4>70 8;8 10mg 1070/kg B.<. 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B.<.!2@JEGC2AB28B5;=>AB :J< chloroquine 8/8;8 proguanil, G5@=>4@>1=0 8;8 1J1@5G=0 =54>AB0BJG=>AB, 0=0<=5AB8G=8 40==8 70 5?8;5?A8O 8;8 ?A>@8078A.#?>B@510B0 =0 chloroquine <>65 40 ?@548728:0 =0<0;5=85 =0 8<C==8O >B3>2>@ ?@8 54=>2@5<5==> ?@8;030=5 =0 8=B@045@<0;=0 ?@>B82>1OA=0 20:A8=0.Mefloquine (Lariam) B01;. 250mg5mg/kg B.<. A54<8G=> 0 2J7@0AB=8: 250mg  1 B01;. A54<8G=>0?>G20 A5 =09-<0;:> 54=0 A54<8F0 (?@5?>@JG20 A5 2  3 A54<8F8) ?@548 ?@8AB830=5 2 @8A:>28O @09>= 8 A5 ?@>4J;6020 4> 4 A54<8F8 A;54 =0?CA:0=5B> <C5 A5 ?@5?>@JG20 ?@57 ?J@28 B@8<5ABJ@57>?0A5=5 A5 ?@5?>@JG20 70 45F0 ?>4 5 :3. B.<.!2@JEGC2AB28B5;=>AB :J< mefloquine. A8E8G=8 (2:;. 45?@5A8O) 8;8 :>=2C;A82=8 @07AB@>9AB20 8 0=0<=5AB8G=8 40==8 70 B56:8 =5@2=>?A8E8G=8 701>;O20=8O. !J?JBAB20I0 B5@0?8O A halofantrine 8;8 ;5G5=85 A mefloquine ?@57 ?@54E>4=8B5 4 A54<8F8564C ;5G5=85 A quinine 8 ?@85<0 =0 mefloquine B@O120 40 8<0 =09-<0;:> 12 G0A>2 8=B5@20;. 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